Integration of ultra-high-pressure liquid chromatography–tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke†,10.1039/D0CC02329A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Integration of ultra-high-pressure liquid chromatography–tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke†

Lijian Zhang,Fei Ma,Ao Qi,Lulu Liu,Junjie Zhang,Simin Xu,Qisheng Zhong,Yusen Chen,Chun-yang Zhang,Chun Cai

Chemical Communications Pub Date : 05/07/2020 00:00:00 , DOI:10.1039/D0CC02329A

Abstract

We report for the first time the integration of ultra-high-pressure liquid chromatography–tandem mass spectrometry with machine learning for identifying fatty acid metabolite biomarkers of ischemic stroke. In particular, we develop an optimal model to discriminate ischemic stroke patients from healthy persons with 100% sensitivity and 93.18% specificity. This research may facilitate understanding the roles of fatty acid metabolites in stroke occurrence, holding great potential in clinical stroke diagnosis.