A new strategy to construct a CC–CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums†‡,10.1039/C3CC49059A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

A new strategy to construct a CC–CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums†‡

Guang-Cun Ge,Xiao-Jun Huang,Chang-Hua Ding,Shi-Li Wan,Li-Xin Dai

Chemical Communications Pub Date : 01/27/2014 00:00:00 , DOI:10.1039/C3CC49059A

Abstract

A new strategy for the construction of a C [double bond, length as m-dash] C–CF₃ subunit has been developed via CuBr-catalyzed domino cyclization–trifluoromethylation of homopropargyl amines with Umemoto's reagent. 4-Trifluoromethyl-2,3-dihydro-pyrroliums were produced in high yields. The usefulness of these products has been demonstrated by the transformation of them into various other trifluoromethylated molecules.