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Michael, Michael–aldol and Michael–Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives
Steven V. Ley,Darren J. Dixon,Richard T. Guy,Félix Rodríguez,Tom D. Sheppard
Organic & Biomolecular Chemistry Pub Date : 10/19/2005 00:00:00 , DOI:10.1039/B512410G
Abstract

Consecutive coupling reactions of butane-2,3-diacetal protected glycolic acid derivatives with Michael acceptors and aldehydes are reported. An enantiopure sample of this building block was used to kinetically resolve a chiral Michael acceptor present as a racemic mixture of enantiomers.

Graphical abstract: Michael, Michael–aldol and Michael–Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives
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