Maleimide as an efficient nucleophilic partner in the aza-Morita–Baylis–Hillman reaction: synthesis of chiral 3-substituted-3-aminooxindoles†,10.1039/C5OB00182J

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Maleimide as an efficient nucleophilic partner in the aza-Morita–Baylis–Hillman reaction: synthesis of chiral 3-substituted-3-aminooxindoles†

Akshay Kumar,Vivek Sharma,Jasneet Kaur,Naveen Kumar,Swapandeep Singh Chimni

Organic & Biomolecular Chemistry Pub Date : 02/24/2015 00:00:00 , DOI:10.1039/C5OB00182J

Abstract

A highly enantioselective Morita–Baylis–Hillman reaction of maleimides with isatin derived ketimines has been developed to obtain enantiomerically enriched 3-substituted-3-aminooxindoles using β-isocupreidine as an organocatalyst. Maleimide acting as a nucleophile provides products with up to 99% ee.