Mechanistic insight into oxidized N,N-dimethylacetamide as a source of formaldehyde related derivatives†,10.1039/C7RE00199A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Mechanistic insight into oxidized N,N-dimethylacetamide as a source of formaldehyde related derivatives†

Daniel Zewge,Xiaodong Bu,Huaming Sheng,Yizhou Liu,Zhu Liu,Brett Harman,Mikhail Reibarkh,Xiaoyi Gong

Reaction Chemistry & Engineering Pub Date : 02/06/2018 00:00:00 , DOI:10.1039/C7RE00199A

Abstract

A hemiaminal derivative identified during preparation of the penultimate of ceftolozane 1, mandated a thorough investigation of the source of the impurity. N,N-Dimethylacetamide (DMAc) subjected to oxidation was found to be the culprit generating oxidized products that serve as sources of the hemiaminal derivative. Identification of DMAc as a source of formaldehyde derivatives and the mechanism of DMAc oxidation are elaborated.