Kinetic resolution of racemic amines using provisional molecular chirality generated by spontaneous crystallization†
Masami Sakamoto,Kazuyuki Fujita,Fumitoshi Yagishita,Atsushi Unosawa,Takashi Mino,Tsutomu Fujita
Chemical Communications Pub Date : 03/07/2011 00:00:00 , DOI:10.1039/C1CC00081K
Abstract

N-(2-methoxy-1-naphthoyl)pyrrolidine afforded chiral crystals by spontaneous crystallization. The molecular chirality in the crystal was retained after dissolving the crystals in a cooled solvent. Kinetic resolution of racemic amines was performed using the provisional chiral molecular conformation derived from chiral crystals.

Graphical abstract: Kinetic resolution of racemic amines using provisional molecular chirality generated by spontaneous crystallization