Modular synthesis of optically active lactones by Ru-catalyzed asymmetric allylic carboxylation and ring-closing metathesis reaction†
Koichiro Takii,Naoya Kanbayashi,Kiyotaka Onitsuka
Chemical Communications Pub Date : 03/14/2012 00:00:00 , DOI:10.1039/C2CC18137A
Abstract

A new synthetic route to optically active unsaturated γ- and δ-lactones has been demonstrated via asymmetric allylic carboxylation with a planar-chiral Cp′Ru catalyst and ring-closing metathesis reaction with a Grubbs II catalyst, and successfully applied to the enantioselective synthesis of (R)-(−)-massoialactone.

Graphical abstract: Modular synthesis of optically active lactones by Ru-catalyzed asymmetric allylic carboxylation and ring-closing metathesis reaction