Importance of the backbone conformation of (−)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes†,10.1039/B818903J

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Importance of the backbone conformation of (−)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes†

Kenichiro Shimokawa,Ryoka Miwa,Kaoru Yamada

Organic & Biomolecular Chemistry Pub Date : 01/07/2009 00:00:00 , DOI:10.1039/B818903J

Abstract

Key relationships between the intramolecular H-bond-derived backbone conformation and the bioactivity of the novel fat-accumulation inhibitor (−)-ternatin are examined by analyses of the NMR spectroscopic data and CD spectra of designed analogues. The results reveal that the β-turn structure of (−)-ternatin is responsible for its potent fat-accumulation inhibitory effect against 3T3-L1 murine adipocytes.