Intramolecular addition of benzyl anion to alkyne utilizing [1,2]-phospha-Brook rearrangement under Brønsted base catalysis†,10.1039/C7OB02059G

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Intramolecular addition of benzyl anion to alkyne utilizing [1,2]-phospha-Brook rearrangement under Brønsted base catalysis†

Azusa Kondoh,Ryosuke Ozawa,Takuma Aoki,Masahiro Terada

Organic & Biomolecular Chemistry Pub Date : 08/22/2017 00:00:00 , DOI:10.1039/C7OB02059G

Abstract

A novel reaction system for intramolecular addition of benzyl anions to alkynes was developed by utilizing the [1,2]-phospha-Brook rearrangement under Brønsted base catalysis. The present reaction is a rare example of a catalytic addition reaction of an unstabilized benzyl anion under Brønsted base catalysis.