A Pd(ii)-catalyzed asymmetric approach toward chiral [3.3.1]-bicyclic ketals using 2-hydroxyphenylboronic acid as a pro-bis(nucleophile)†
Feijun Wang,Feng Chen,Mingliang Qu,Teng Li,Yunlong Liu
Chemical Communications Pub Date : 03/07/2013 00:00:00 , DOI:10.1039/C3CC00295K
Abstract
Enantioselective Pd(II)-catalyzed construction of [3.3.1]-bicyclic ketals from 2-hydroxyphenylboronic acid 1 and enone3 is reported, yielding enantioenriched [3.3.1]-bicyclic ketals in up to 97% yields and 98% ee.
![Graphical abstract: A Pd(ii)-catalyzed asymmetric approach toward chiral [3.3.1]-bicyclic ketals using 2-hydroxyphenylboronic acid as a pro-bis(nucleophile)](http://hg.y866.cn/compound/lib/scimg/usr/1/C3CC00295K.jpg)
