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Inorganic base catalyzed synthesis of (2-amino-3-cyano-4H-chromene-4-yl) phosphonate derivatives via multi-component reaction under mild and efficient conditions†
Peng Dai,Gaofeng Zha,Xiaoyan Lai,Wei Liu,Qianwen Gan,Yongcun Shen
RSC Advances Pub Date : 11/06/2014 00:00:00 , DOI:10.1039/C4RA09359C
Abstract

Various (2-amino-3-cyano-4H-chromene-4-yl) phosphonate derivatives were synthesized in good to excellent yields by condensation of diverse substituted salicylaldehyde, malononitrile and diethyl phosphite or diphenyl phosphite using anhydrous lithium hydroxide as a catalyst under mild conditions.

Graphical abstract: Inorganic base catalyzed synthesis of (2-amino-3-cyano-4H-chromene-4-yl) phosphonate derivatives via multi-component reaction under mild and efficient conditions
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