Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis†,10.1039/C9CC07009E

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis†

Won Young Kim,Miae Won,Abbas Salimi,Amit Sharma,Jong Hyeon Lim,Seung-Hae Kwon,Joo-Yeong Jeon,Jin Yong Lee,Jong Seung Kim

Chemical Communications Pub Date : 10/04/2019 00:00:00 , DOI:10.1039/C9CC07009E

Abstract

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.