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1,6-Conjugate addition of zinc alkyls to para-quinone methides in a continuous-flow microreactor†
Abhijeet S. Jadhav,Ramasamy Vijaya Anand
Organic & Biomolecular Chemistry Pub Date : 11/01/2016 00:00:00 , DOI:10.1039/C6OB02277D
Abstract

An efficient method for the synthesis of alkyl diarylmethanes through the 1,6-conjugate addition of dialkylzinc reagents to para-quinone methides (p-QMs) has been developed under continuous flow conditions using a microreactor. This protocol allows to access unsymmetrical alkyl diarylmethanes in moderate to excellent yields using a wide range of p-QMs and dialkylzinc reagents. Interestingly, this transformation worked well without the requirement of a catalyst.

Graphical abstract: 1,6-Conjugate addition of zinc alkyls to para-quinone methides in a continuous-flow microreactor
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