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Metal-free DDQ-mediated oxidative C–O coupling of acetalic sp3 C–H bonds with carboxylic acids†
Jiang-Sheng Li,Yuan Xue,Dong-Mei Fu,Dao-Lin Li,Zhi-Wei Li,Wei-Dong Liu,Huai-Lin Pang,Yue-Fei Zhang,Zhong Cao,Ling Zhang
RSC Advances Pub Date : 09/24/2014 00:00:00 , DOI:10.1039/C4RA08627A
Abstract

A simple and efficient DDQ-mediated oxidative C–O coupling reaction between acetalic sp3 C–H and carboxylic acid O–H bonds has been developed. This novel transformation smoothly proceeds without any metal catalyst and allows for the highly efficient synthesis of (un)symmetric glycol diesters in a single step.

Graphical abstract: Metal-free DDQ-mediated oxidative C–O coupling of acetalic sp3 C–H bonds with carboxylic acids
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