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Metal-free syntheses of N-functionalized and NH-1,2,3-triazoles: an update on recent developments
Tomas Opsomer,Wim Dehaen
Chemical Communications Pub Date : 01/04/2021 00:00:00 , DOI:10.1039/D0CC06654K
Abstract

An overview of the latest developments in the metal-free synthesis of non-benzo-fused N-functionalized and NH-1,2,3-triazoles is provided in this feature article. Synthetic studies that appeared from 2016 until August 2020 are organized according to a wide-ranging classification, comprising oxidative and eliminative azide-dipolarophile cycloadditions, diazo transfer reactions and N-tosylhydrazone-mediated syntheses. The newly developed methods constitute a significant contribution to the field of 1,2,3-triazole synthesis in terms of structural variation via either the exploration of novel reactions, or the exploitation of existing methodologies.

Graphical abstract: Metal-free syntheses of N-functionalized and NH-1,2,3-triazoles: an update on recent developments
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