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Micellar catalysis-enabled sustainable ppm Au-catalyzed reactions in water at room temperature†
Piyatida Klumphu,Camille Desfeux,Yitao Zhang,Sachin Handa,Fabrice Gallou,Bruce H. Lipshutz
Chemical Science Pub Date : 07/20/2017 00:00:00 , DOI:10.1039/C7SC02405C
Abstract

Several ppm level gold-catalyzed reactions enabled by the ligand HandaPhos can be performed at room temperature in aqueous nanoreactors composed of the surfactant Nok. Variously substituted allenes undergo cycloisomerization leading to heterocyclic products in good yields. Likewise, cyclodehydration is also illustrated under similar conditions, as is an intermolecular variant, hydration of terminal alkynes. Recycling of the catalyst and reaction medium is also illustrated. A low E factor associated with limited solvent use and therefore, waste generation, documents the greenness of this process.

Graphical abstract: Micellar catalysis-enabled sustainable ppm Au-catalyzed reactions in water at room temperature
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