Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function†
Chaoxuan Li,Feifei Zhang,Wendy L. Kelly
Chemical Communications Pub Date : 11/08/2011 00:00:00 , DOI:10.1039/C1CC14281J
Abstract
The seventh residue of thiostrepton is predicted to be critical for antibacterial activity. Substitution of Thr7 in the thiostrepton precursor peptide disrupts both biological activity and the successful biosynthesis of analogs.
