Laser synthesis: a solvent-free approach for the preparation of phenylthiazolo[5,4-b]pyridine derivatives†,10.1039/D0RA10094C

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Laser synthesis: a solvent-free approach for the preparation of phenylthiazolo[5,4-b]pyridine derivatives†

Joana F. Campos,Nicolas Dumuis,Hervé Rabat,Nadjib Semmar,Sabine Berteina-Raboin

RSC Advances Pub Date : 01/27/2021 00:00:00 , DOI:10.1039/D0RA10094C

Abstract

We describe here a rapid and straightforward solvent-free method to access phenylthiazolo[5,4-b]pyridines using a Nd-YAG laser NANO-NY81-10 (λ = 355 nm, 10 Hz pulse frequency; 8 ns pulse duration). This newly presented method successfully brings several improvements to the laser assisted synthesis of N,S-heterocycles. We are able to provide a solvent-, metal- and base-free method with good yield and a substantial reduction in reaction time.