Isolation, structure elucidation, and KDD study of (−)-Celosine, a new skeleton with potent anti-atherosclerosis activity†,10.1039/C7RA08683K

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Isolation, structure elucidation, and KDD study of (−)-Celosine, a new skeleton with potent anti-atherosclerosis activity†

Zhiliang Lv,Bin Hu,Jifa Zhang,Peng Du,Man Wang,Linlin Xiao,Peiming Yang

RSC Advances Pub Date : 11/01/2017 00:00:00 , DOI:10.1039/C7RA08683K

Abstract

Natural (−)-Celosine was isolated as a novel endocyclicditerpene with an unprecedented skeleton from Celosia cristata L. Its structure was established by comprehensive 1D and 2D NMR spectroscopic analysis in combination with single-crystal X-ray crystallographic diffraction of synthesized (+)-Celosine. (−)-Celosine was expected to have an anti-atherosclerotic activity in vivo, and myeloperoxidase (MPO) expression may be the mechanism underlying this anti-atherosclerotic activity.