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K2S2O8/arenesulfinate: an unprecedented thiolating system enabling selective sulfenylation of indoles under metal-free conditions†
Honghua Rao,Ping Wang,Jianchun Wang,Zhongfeng Li,Xinzhan Sun,Shengli Cao
RSC Advances Pub Date : 09/26/2014 00:00:00 , DOI:10.1039/C4RA08669D
Abstract

An unprecedented thiolating system K2S2O8/arenesulfinate is described for selective sulfenylation of indoles in CH3CN/H2O. This metal-free strategy enables a simple, efficient and environment-benign approach to the pharmaceutically important candidates, 3-arylthioindoles. Catalytically reactive halogen and aryl groups are well tolerated.

Graphical abstract: K2S2O8/arenesulfinate: an unprecedented thiolating system enabling selective sulfenylation of indoles under metal-free conditions
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