Veterinary medicines are extensively applied in food producing animals for the treatment of various bacterial infections, so the risk of occurrence of unwanted residues in edible products exists. This review is focused on the methods of sample preparation for determination of veterinary residues in food matrices by porous monolith microextraction-based techniques. Microextraction techniques using porous monoliths offer several advantages, including miniaturization, automation, high-throughput performance, and on-line coupling with analytical instruments, as well as being solvent-free and portable. In this review the focus is on application of porous monolith microextraction techniques for veterinary drug residues analysis. The general approaches used to synthesize organic polymer and silica monolithic materials are briefly described. Several porous monolith microextraction formats, including in-tube solid-phase microextraction (in-tube SPME), stir bar sorptive extraction (SBSE) and stir rod sorptive extraction (SRSE) modes based on porous monoliths are critically evaluated and the applications of these techniques in veterinary drug residues analysis are summarized.