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On the activation of valerolactam with triflic anhydride: the synthesis of ω-trifluorosulfonamido dipeptides using a transpeptidation reaction under mild conditions
Nikolai Kuhnert,Ian Clemens,Rodney Walsh
Organic & Biomolecular Chemistry Pub Date : 03/29/2005 00:00:00 , DOI:10.1039/B417779G
Abstract

The activation of valerolactam with triflic anhydride is studied in detail, initially producing an O-triflated lactam, which rearranges, following the addition of base at higher temperatures, to an N-triflated derivative. This reacts with a series of nucleophiles to produce esters and amides, which are formally dipeptides of ω-amino acids.

Graphical abstract: On the activation of valerolactam with triflic anhydride: the synthesis of ω-trifluorosulfonamido dipeptides using a transpeptidation reaction under mild conditions
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