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One-pot fluorination followed by Michael addition or Robinson annulation for preparation of α-fluorinated carbonyl compounds†
Wen-Bin Yi,Xin Huang,Chun Cai,Wei Zhang
Green Chemistry Pub Date : 09/12/2012 00:00:00 , DOI:10.1039/C2GC36166C
Abstract

Fluorination followed by the Michael addition or Robinson annulation of 1,3-dicarbonyl compounds is introduced for the synthesis of acyclic and cyclic α-fluoro-β-ketoesters and α-fluoro-1,3-diketones. The decarboxylation step can also be added to the reaction sequence. High efficiency is achieved by the microwave heating and atom economic one-pot synthesis.

Graphical abstract: One-pot fluorination followed by Michael addition or Robinson annulation for preparation of α-fluorinated carbonyl compounds
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