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Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes†
E. M. Rigsbee,C. Zhou,C. M. Rasik,A. Z. Spitz,A. J. Nichols,M. K. Brown
Organic & Biomolecular Chemistry Pub Date : 09/30/2015 00:00:00 , DOI:10.1039/C5OB01837D
Abstract

A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families.

Graphical abstract: Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes
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