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N-heterocyclic carbene-catalyzed cyclocondensation of 2-aryl carboxylic acids and enones: highly enantioselective synthesis of δ-lactones†
Jin-Tang Cheng,Xiang-Yu Chen
Organic & Biomolecular Chemistry Pub Date : 11/27/2014 00:00:00 , DOI:10.1039/C4OB02330G
Abstract

The enantioselective N-heterocyclic carbene-catalyzed [4 + 2] cyclocondensation of 2-aryl carboxylic acids and enones was developed, affording the corresponding chiral δ-lactones in good yields with good diastereo- and high enantioselectivities.

Graphical abstract: N-heterocyclic carbene-catalyzed cyclocondensation of 2-aryl carboxylic acids and enones: highly enantioselective synthesis of δ-lactones
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