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Nickel-catalyzed cross-coupling of aldehydes with aryl halides via hydrazone intermediates†
Leiyang Lv,Xi-Jie Dai,Chen-Chen Li,Lu Li,Chao-Jun Li
Chemical Communications Pub Date : 01/22/2018 00:00:00 , DOI:10.1039/C7CC09290C
Abstract

Traditional cross-couplings require stoichiometric organometallic reagents. A novel nickel-catalyzed cross-coupling reaction between aldehydes and aryl halides via hydrazone intermediates has been developed, merging the Wolff–Kishner reduction and the classical cross-coupling reactions. Aromatic aldehydes, aryl iodides and aryl bromides are especially effective in this new cross-coupling chemistry.

Graphical abstract: Nickel-catalyzed cross-coupling of aldehydes with aryl halides via hydrazone intermediates
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