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A novel reaction of gem-difluorocyclopropyl ketones with nitriles leading to 2-fluoropyrroles†
Tang-Po Yang,Jin-Hong Lin,Qing-Yun Chen,Ji-Chang Xiao
Chemical Communications Pub Date : 08/29/2013 00:00:00 , DOI:10.1039/C3CC45456H
Abstract

The CF3SO3H-promoted ring opening of gem-difluorocyclopropyl ketones prefers to undergo proximal bond cleavage and the subsequent cyclization with nitriles occurred smoothly to give 2-fluoropyrroles.

Graphical abstract: A novel reaction of gem-difluorocyclopropyl ketones with nitriles leading to 2-fluoropyrroles
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