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Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: a concise route to access chromans†
Chamini V. Karunaratne,Ryan G. Sarkisian,Jennifer Reeves,Yongming Deng,Kraig A. Wheeler,Hong Wang
Organic & Biomolecular Chemistry Pub Date : 04/07/2017 00:00:00 , DOI:10.1039/C7OB00753A
Abstract

An atom-economical multicomponent cascade reaction of salicylaldehydes, cyclohexanones and arylamines has been developed for the synthesis of three-ring fused chromans. This reaction was achieved through cooperative enamine–metal Lewis acid assisted Brønsted acid catalysis, furnishing the products in excellent yields with good diastereoselectivity.

Graphical abstract: Multicomponent reaction through cooperative trio catalysis incorporating enamine, Brønsted acid and metal Lewis acid catalysis: a concise route to access chromans
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