A practical synthesis of d-erythro-sphingosine using a cross-metathesis approach†
Staffan Torssell,Peter Somfai
Organic & Biomolecular Chemistry Pub Date : 04/20/2004 00:00:00 , DOI:10.1039/B403568B
Abstract

Starting from a vinylepoxide, a short and practical synthesis of D-erythro-sphingosine is described. The key transformations are a regioselective opening of the vinylepoxide and an E-selective cross-metathesis, affording the target molecule in 5 steps and 51% overall yield.

Graphical abstract: A practical synthesis of d-erythro-sphingosine using a cross-metathesis approach