A rapid screen for molecules that form duplex to duplex crosslinks in DNA†
María J. Marín,Benjamin D. Rackham,Andrew N. Round,Lesley A. Howell,David A. Russell,Mark Searcey
Chemical Communications Pub Date : 08/22/2013 00:00:00 , DOI:10.1039/C3CC45600E
Abstract
We describe a gold nanoparticle based assay that can rapidly determine the crosslinking of DNA duplexes by ligands. Such compounds have potential in targeting highly compacted DNA such as that found in the nucleosome.
