Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster†
Sian M. Cooper,Russell J. Cox,John Crosby,Matthew P. Crump,Joanne Hothersall,Wanpen Laosripaiboon,Thomas J. Simpson,Christopher M. Thomas
Chemical Communications Pub Date : 01/17/2005 00:00:00 , DOI:10.1039/B414781B
Abstract
Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.
