960化工网
Mannich–Michael versus formal aza-Diels–Alder approaches to piperidine derivatives
P. Ricardo Girling,Takao Kiyoi,Andrew Whiting
Organic & Biomolecular Chemistry Pub Date : 03/09/2011 00:00:00 , DOI:10.1039/C0OB00996B
Abstract

A review into the aza-Diels–Alder reaction, mainly concentrating on literature examples that form piperidin-4-ones from the reaction of imines and electron rich dienes or enones, either through a Lewis acidic/Brønsted acid approach or through the use of an organocatalyst. This review questions whether the mechanism of the aza-Diels–Alder reaction is step wise as opposed to concerted when using oxygenated dienes.

Graphical abstract: Mannich–Michael versus formal aza-Diels–Alder approaches to piperidine derivatives
平台客服
平台客服
平台在线客服