LDA-mediated synthesis of ortho-cyanated diarylmethanes by reaction of fluoroarene with arylacetonitrile at room temperature†,10.1039/C6QO00363J

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

LDA-mediated synthesis of ortho-cyanated diarylmethanes by reaction of fluoroarene with arylacetonitrile at room temperature†

Fang Liang,Xinfei Ji,Juan Zhang,Song Cao

Organic Chemistry Frontiers Pub Date : 08/26/2016 00:00:00 , DOI:10.1039/C6QO00363J

Abstract

An efficient and facile method for the synthesis of ortho-cyanated diarylmethane by reaction of fluoroarene with arylacetonitrile in the presence of LDA (lithium diisopropylamide) at room temperature was developed. The reaction of arylacetonitrile with electron-rich fluoroarene involves the formation of an aryne intermediate.