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2-Pyrrolecarbaldiminato–Cu(ii) complex catalyzed three-component 1,3-dipolar cycloaddition for 1,4-disubstituted 1,2,3-triazoles synthesis in water at room temperature†
Changjian Zhou,Jie Zhang,Ping Liu,Jianwei Xie,Bin Dai
RSC Advances Pub Date : 12/17/2014 00:00:00 , DOI:10.1039/C4RA13423K
Abstract

2-Pyrrolecarbaldiminato–Cu(II) complexes were established as efficient catalysts for the three-component 1,3-dipolar cycloaddition reaction of benzyl halides and sodium azide with terminal alkynes in water at room temperature, and several regioselective 1,4-disubstituted 1,2,3-triazoles have been synthesized under the reaction conditions in 55–97% yields.

Graphical abstract: 2-Pyrrolecarbaldiminato–Cu(ii) complex catalyzed three-component 1,3-dipolar cycloaddition for 1,4-disubstituted 1,2,3-triazoles synthesis in water at room temperature
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