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Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy†
Masafumi Ueda,Kengo Ashizawa,Kouta Sugikawa,Kazuya Koumoto,Takeshi Nagasaki,Atsushi Ikeda
Organic & Biomolecular Chemistry Pub Date : 10/28/2016 00:00:00 , DOI:10.1039/C6OB02142E
Abstract

Arylboronate esters bearing methyl groups in both of their ortho positions were stably incorporated into lipid membranes at high concentrations without undergoing hydrolysis to the corresponding boronic acids. This method could be used in combination with previous methods to increase the maximum ratio of boron atoms in liposomal boron carriers.

Graphical abstract: Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy
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