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Mechanistic divergence of two closely related aldol-like enzyme-catalysed reactions†
Meekyung Ahn,Amy L. Pietersma,Linley R. Schofield,Emily J. Parker
Organic & Biomolecular Chemistry Pub Date : 10/06/2005 00:00:00 , DOI:10.1039/B511661A
Abstract

The analysis of the interaction of threose 4-phosphate and 2-deoxyerythrose 4-phosphate with 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS) reveals previously unrecognised mechanistic differences between the DAH7PS-catalysed reaction and that catalysed by the closely related enzyme, 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS).

Graphical abstract: Mechanistic divergence of two closely related aldol-like enzyme-catalysed reactions
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