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Phosphine-catalyzed regioselective Michael addition to allenoates†
Vasudeva Rao Gandi,Yixin Lu
Chemical Communications Pub Date : 09/09/2015 00:00:00 , DOI:10.1039/C5CC06197K
Abstract

The first phosphine catalysed Michael addition of arylcyanoacetates to allenoates has been developed, and the β-selective products with a quaternary center were obtained in excellent yields. This unusual regioselectivity may open new opportunities to access interesting molecular structures.

Graphical abstract: Phosphine-catalyzed regioselective Michael addition to allenoates
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