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Metal-free, aerobic ketooxygenation of alkenes using hydroxamic acids†
Valerie A. Schmidt,Erik J. Alexanian
Chemical Science Pub Date : 02/03/2012 00:00:00 , DOI:10.1039/C2SC01042A
Abstract

A metal-free, radical-mediated alkene ketooxygenation is described. This four-electron alkene oxidation delivers α-oxyketones directly from simple alkenes with high levels of regio- and stereocontrol. The aerobic process capitalizes on the unique reactivity of amidoxyl radicals in intra- and intermolecular alkene additions.

Graphical abstract: Metal-free, aerobic ketooxygenation of alkenes using hydroxamic acids
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