Nickel-catalyzed asymmetric α-arylation of ketone enolates†
Guoshu Chen,Fuk Yee Kwong,Hoi On Chan,Wing-Yiu Yu,Albert S. C. Chan
Chemical Communications Pub Date : 02/21/2006 00:00:00 , DOI:10.1039/B601691J
Abstract
An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed α-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.
