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Nickel-catalyzed regioselective arylation of aromatic amides with aryl iodides enabled by an N,O-bidentate directing group†
Guan-Wu Wang,Hao Chen,Lei Wang
Organic & Biomolecular Chemistry Pub Date : 10/30/2018 00:00:00 , DOI:10.1039/C8OB02237B
Abstract

A bidentate directing group enabled regioselective arylation of C(sp2)–H bonds in aromatic carboxamides with aryl iodides under nickel-catalysis is reported, which provides the corresponding products in moderate to good yields. This protocol using the inexpensive and low-toxic Ni catalyst can tolerate a wide range of functional groups.

Graphical abstract: Nickel-catalyzed regioselective arylation of aromatic amides with aryl iodides enabled by an N,O-bidentate directing group
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