NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species†,10.1039/C5RA17553D

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species†

C. A. Romero,T. Grkovic,J. Han,L. Zhang,J. R. J. French,D. I. Kurtböke,R. J. Quinn

RSC Advances Pub Date : 11/30/2015 00:00:00 , DOI:10.1039/C5RA17553D

Abstract

A new NMR-based method to access to the unique components of the drug-like natural product metabolome of termite-gut associated actinomycetes has been developed. This approach was used to accelerate the identification of lead-like enhanced fractions containing small molecules with unique spectral patterns. The effectiveness of the approach was demonstrated by the isolation and identification of six new natural products, namely, actinoglycosidines A (1) and B (2), actinopolymorphol D (3), niveamycin A (7), B (8) and C (9).