Metal to ligand charge transfer induced DNA photobinding in a Ru(ii)–Pt(ii) supramolecule using red light in the therapeutic window: a new mechanism for DNA modification†
Samantha L. H. Higgins,Allison J. Tucker,Brenda S. J. Winkel,Karen J. Brewer
Chemical Communications Pub Date : 11/10/2011 00:00:00 , DOI:10.1039/C1CC15780A
Abstract
The Ru(II)–Pt(II) supramolecular complex, [(Ph2phen)2Ru(dpp)PtCl2]2+, displays a new mechanism for DNA modification: photobinding through a 3MLCT excited state. Gel shift analysis, selective DNA precipitation, and DNA melting point experiments support efficient covalent DNA binding following visible light excitation.
