A regioselective C7 bromination and C7 palladium-catalyzed Suzuki–Miyaura cross-coupling arylation of 4-substituted NH-free indazoles†,10.1039/D0RA08598G

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

A regioselective C7 bromination and C7 palladium-catalyzed Suzuki–Miyaura cross-coupling arylation of 4-substituted NH-free indazoles†

Nabil El Brahmi,Jérôme Graton,Didier Dubreuil,Sylvain Collet,Monique Mathé-Allainmat,Mohamed Akssira,Jacques Lebreton,Saïd El Kazzouli

RSC Advances Pub Date : 02/10/2021 00:00:00 , DOI:10.1039/D0RA08598G

Abstract

A direct and efficient regioselective C7-bromination of 4-substituted 1H-indazole has been achieved. Subsequently, a successful palladium-mediated Suzuki–Miyaura reaction of C7-bromo-4-substituted-1H-indazoles with boronic acids has been performed under optimized reaction conditions. A series of new C7 arylated 4-substituted 1H-indazoles was obtained in moderate to good yields.