Micelle promoted multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction in water†
Atul Kumar,Maneesh Kumar Gupta,Mukesh Kumar,Deepti Saxena
RSC Advances Pub Date : 11/30/2012 00:00:00 , DOI:10.1039/C2RA22428C
Abstract

An efficient micelle promoted one-pot synthesis of 3-amino alkylated indoles has been developed via a three-component Mannich-type reaction from secondary amines, aldehydes and indoles in water under mild reaction conditions. In this Mannich-type reaction, micelles stabilize iminium ions, which undergo a nucleophilic addition of the indole to give 3-amino alkylated indoles in very good yields.

Graphical abstract: Micelle promoted multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction in water