Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold†‡
Ana I. Sánchez,Ricardo Meneses,José M. Mínguez,Araceli Núñez,Rafael R. Castillo,Fabiana Filace,Carolina Burgos,Juan J. Vaquero,Julio Álvarez-Builla,Alvaro Cortés-Cabrera,Federico Gago,Emma Terricabras,Víctor Segarra
Abstract
A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds.
