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One-pot double functionalisation of π-deficient heterocyclic lithium reagents†
Anthony Chartoire,Corinne Comoy,Yves Fort
Organic & Biomolecular Chemistry Pub Date : 01/26/2011 00:00:00 , DOI:10.1039/C0OB00734J
Abstract

Herein, we report an efficient method for the double functionalisation of lithiated halogenopyridines, -pyrazines or -furopyridines through a convenient one-pot electrophilic trapping/nucleophilic substitution sequence.

Graphical abstract: One-pot double functionalisation of π-deficient heterocyclic lithium reagents
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