960化工网
N-Heterocyclic carbene-catalyzed stereoselective construction of olefinic carbon–sulfur bonds via cross-coupling reaction of gem-difluoroalkenes and thiols†
Zi-Song Cong,Yang-Guo Li,Lei Chen,Fen Xing
Organic & Biomolecular Chemistry Pub Date : 04/12/2017 00:00:00 , DOI:10.1039/C7OB00599G
Abstract

A novel organocatalytic olefinic carbon–sulfur bond forming reaction was developed. Under the catalysis of 10 mol% stable N-heterocyclic carbene, thiols undergo direct nucleophilic substitution reaction with gem-difluoroalkenes to produce α-fluorovinyl thioethers in high yields with excellent Z-selectivity. In this process, bases are not necessary.

Graphical abstract: N-Heterocyclic carbene-catalyzed stereoselective construction of olefinic carbon–sulfur bonds via cross-coupling reaction of gem-difluoroalkenes and thiols
平台客服
平台客服
平台在线客服