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Nickel-catalyzed cascade carbonylative synthesis of N-benzoyl indoles from 2-nitroalkynes and aryl iodides†
Lingyun Yao,Jun Ying
Organic Chemistry Frontiers Pub Date : 10/05/2021 00:00:00 , DOI:10.1039/D1QO01284C
Abstract

A nickel-catalyzed carbonylative cyclization of 2-nitroalkynes and aryl iodides has been developed for the expedite construction of N-benzoyl indole scaffolds. Using Co2(CO)8 as the CO source, this cascade reaction proceeded with high efficiency to give a variety of N-benzoyl indoles in moderate to high yields. Control experiments were performed as well to gain a better understanding of the reaction mechanism.

Graphical abstract: Nickel-catalyzed cascade carbonylative synthesis of N-benzoyl indoles from 2-nitroalkynes and aryl iodides
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