Organocatalytic asymmetric synthesis of arylindolyl indolin-3-ones with both axial and central chirality†,10.1039/D0CC05432A

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Organocatalytic asymmetric synthesis of arylindolyl indolin-3-ones with both axial and central chirality†

Xudong Wu,Fei Peng,Haijun Yang,Changjin Zhu,Hua Fu

Chemical Communications Pub Date : 09/11/2020 00:00:00 , DOI:10.1039/D0CC05432A

Abstract

An efficient method for chiral phosphoric acid-catalyzed asymmetric synthesis of arylindolyl indolin-3-ones with both axial and central chirality has been developed via the reaction of 3-arylindoles with 2-aryl-3H-indol-3-ones, and the target products were obtained in high yields with excellent enantioselectivity and diastereoselectivity.