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Organosilicon-mediated total synthesis of the triquinane sesquiterpenes (±)-β-isocomene and (±)-isocomene†‡
Arndt W. Schmidt,Thomas Olpp,Elke Baum,Tina Stiffel,Hans-Joachim Knölker
Organic & Biomolecular Chemistry Pub Date : 07/28/2010 00:00:00 , DOI:10.1039/C0OB00051E
Abstract

We describe an efficient total synthesis of the sesquiterpenes (±)-β-isocomene and (±)-isocomene using a Lewis acid-promoted [3 + 2] cycloaddition of allyl-tert-butyldiphenylsilane as the key-step.

Graphical abstract: Organosilicon-mediated total synthesis of the triquinane sesquiterpenes (±)-β-isocomene and (±)-isocomene
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